Usually means: Enhancement of a protein's capabilities.
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We found 5 dictionaries that define the word gain of function:

General (2 matching dictionaries)
  1. Gain-of-function, Gain of function: Wikipedia, the Free Encyclopedia
  2. gain of function: Wiktionary

Business (1 matching dictionary)
  1. Gain-of-function, Gain of function: Legal dictionary

Computing (1 matching dictionary)
  1. Gain-of-function, Gain of function: Encyclopedia

Medicine (1 matching dictionary)
  1. Gain-of-function, Gain of function: Medical dictionary

Definitions from Wiktionary (gain of function)

noun:  (genetics) An increase in virulence or transmissibility

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