Richard Dean Tuttle (born July 12, 1941) is an American postminimalist artist known for his small, casual, subtle, intimate works.

Lisa Gracia Tuttle (born September 16, 1952) is a British science fiction, fantasy, and horror author.

Molly Rose Tuttle (born January 14, 1993) is an American vocalist, songwriter, banjo player, guitarist, recording artist, and teacher in the bluegrass tradition.

Julia DeForest Tuttle (née Sturtevant; January 22, 1849 – September 14, 1898) was an American businesswoman who owned the property upon which Miami, Florida, was built.

(August 29, 1907 – May 28, 1986) an American actress and acting coach, who made the transition from vaudeville to radio, and later to films and television.

The (also called "Bookville" by former residents) an encampment of banished, registered sex offenders who were living beneath the Julia Tuttle Causeway—a highway connecting Miami, Florida to Miami Beach, Florida, United States—from 2006 to April 2010.

Robert Holmes Tuttle (born August 4, 1943) is a businessman specializing in car dealerships.

(November 14, 1879 – May 28, 1935) an American lawyer and sportsman.

William Julian Tuttle (April 13, 1912 – July 27, 2007) was an American make-up artist.

Shyheim Devonte Tuttle (born October 20, 1995) is an American professional football nose tackle for the Carolina Panthers of the National Football League.

Edward Burnham Tuttle Jr. (August 11, 1945 – June 21, 2020) was an American architect and interior designer best known for his works of hotel architecture.