Native Americans (also called American Indians, First Americans, or Indigenous Americans) are the Indigenous peoples of the United States, particularly of the lower 48 states and Alaska.

The history of Native Americans in the United States began before the founding of US, tens of thousands of years ago with the settlement of the Americas by the Paleo-Indians.

Slavery among Native Americans in the United States includes slavery by and enslavement of Native Americans roughly within what is currently the United States of America.

Many Native Americans in the United States have been harmed by, or become addicted to, drinking alcohol.