Usually means: Children differentiated by biological sex.
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We found 12 dictionaries that define the word boys and girls:

General (10 matching dictionaries)
  1. boys-and-girls: Merriam-Webster
  2. boys-and-girls: Vocabulary.com
  3. boys-and-girls: Wordnik
  4. boys and girls: Wiktionary
  5. boys-and-girls: Dictionary.com
  6. Boys And Girls, Boys and Girls (Human League song), Boys and Girls (Pixie Lott song), Boys and Girls (TV series), Boys and Girls (The Human League song), Boys and Girls (The Office), Boys and Girls (The Office episode), Boys and Girls (album), Boys and Girls (game show), Boys and Girls (short story), Boys and Girls: Wikipedia, the Free Encyclopedia
  7. boys-and-girls: Rhymezone
  8. boys-and-girls: FreeDictionary.org
  9. boys-and-girls: Mnemonic Dictionary
  10. boys-and-girls: TheFreeDictionary.com

Medicine (1 matching dictionary)
  1. boys and girls: Medical dictionary

Slang (1 matching dictionary)
  1. boys and girls: Green’s Dictionary of Slang

Definitions from Wiktionary (boys and girls)

noun:  (idiomatic) Used to address an audience of children, or (jocularly) of adults.
noun:  Synonym of Dutchman's breeches (“the plant Dicentra cucullaria”)

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