We found 2 dictionaries that define the word sweat one's guts out:

General (2 matching dictionaries)

1. sweat one's guts out, sweat one's guts out: Collins English Dictionary
2. sweat one's guts out: Wiktionary

Definitions from Wiktionary (sweat one's guts out) ▸ verb:  (informal) to work very hard. ▸ Words similar to sweat one's guts out ▸ Usage examples for sweat one's guts out ▸ Idioms related to sweat one's guts out ▸ Wikipedia articles (New!) ▸ Words that often appear near sweat one's guts out ▸ Rhymes of sweat one's guts out ▸ Invented words related to sweat one's guts out