Usually means: Peak period of health, vitality.
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We found 8 dictionaries that define the word prime of life:

General (7 matching dictionaries)
  1. prime of life: Vocabulary.com
  2. prime of life: Wiktionary
  3. prime of life: Dictionary.com
  4. prime of life: Rhymezone
  5. prime of life: FreeDictionary.org
  6. prime of life: Mnemonic Dictionary
  7. prime of life: TheFreeDictionary.com

Computing (1 matching dictionary)
  1. prime of life: Encyclopedia

Definitions from Wiktionary (prime of life)

noun:  (idiomatic) The period of one's mature life when one is at a peak of health and performance.

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