Usually means: Reduces or exhausts available resources.
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We found 11 dictionaries that define the word depletive:

General (10 matching dictionaries)
  1. depletive: Merriam-Webster
  2. depletive: Collins English Dictionary
  3. depletive: Wordnik
  4. depletive: Wiktionary
  5. Depletive, depletive: Dictionary.com
  6. Depletive: Online Plain Text English Dictionary
  7. depletive: Webster's Revised Unabridged, 1913 Edition
  8. Depletive: AllWords.com Multi-Lingual Dictionary
  9. depletive: FreeDictionary.org
  10. Depletive: TheFreeDictionary.com

Medicine (1 matching dictionary)
  1. depletive: Merriam-Webster Medical Dictionary

(Note: See deplete as well.)

Definitions from Wiktionary (depletive)

adjective:  Causing depletion.
noun:  Any substance used to deplete.

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