Usually means: Primary symptom indicating a disease.
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We found 5 dictionaries that define the word cardinal symptom:

General (2 matching dictionaries)
  1. cardinal symptom: Wiktionary
  2. cardinal symptom: Dictionary.com

Business (1 matching dictionary)
  1. cardinal symptom: Legal dictionary

Computing (1 matching dictionary)
  1. cardinal symptom: Encyclopedia

Medicine (1 matching dictionary)
  1. cardinal symptom: Medical dictionary

Definitions from Wiktionary (cardinal symptom)

noun:  (medicine) The primary or major symptom by which a diagnosis is made
noun:  (homeopathy) The particular symptom which is regarded most important for choosing the curing substance

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