Sorry, no online dictionaries contain the exact phrase opposite of serene.
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Reverse dictionary results:
1. chaotic
2. turbulent
3. tumultuous
4. agitated
5. restless
6. bestraught
7. intermittent explosive disorder
8. apoplexy
9. deranged
10. frumious
11. ireful
12. irked
13. perturbed
14. raging
15. silly
16. smolderingly
17. amok
18. angry
19. befogged
20. befuddled
21. bestead
22. bollix
23. bristling
24. bummed
25. commoved
26. confounded
27. confused
28. cranked up
29. discombobulated
30. distracted
31. dreader
32. enraged
33. exasperated
34. flummoxed
35. flustered
36. frenzy
37. fuming
38. furious

You can look up the words in the phrase individually using these links:   opposite ?   of ?   serene ?
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