Sorry, no online dictionaries contain the exact phrase opposite of innocuous.
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Reverse dictionary results:
1. harmful
2. dangerous
3. toxic
4. hazardous
5. malignant
6. baneful
7. damageable
8. damaging
9. destructively
10. detrimental
11. hurtful
12. obnoxious
13. prejudicial
14. tortious
15. abhor
16. abhorred
17. abhorrence
18. abhorrency
19. abhorrent
20. abominate
21. abusive
22. attery
23. bale
24. brunt
25. calamitous
26. crippling
27. cruel
28. derisive
29. evil
30. harm
31. hate
32. indignation
33. injurious
34. injuriously
35. injury
36. loathe
37. maleficent

You can look up the words in the phrase individually using these links:   opposite ?   of ?   innocuous ?
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