Sorry, no online dictionaries contain the exact phrase opposite of familiarity.
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Reverse dictionary results:
1. converse
2. conversing
3. cold
4. coy
5. eye
6. home
7. newness
8. old
9. know
10. knowledge
11. liberty
12. acquainted
13. conversant
14. custom
15. experiment
16. experimenting
17. intelligence
18. propagate
19. freedom
20. analytical
21. bow
22. critical
23. cross
24. diligence
25. expert
26. necessity
27. negative
28. nod
29. nous
30. polygamy
31. praxis
32. recognize
33. set
34. switch
35. track
36. turn
37. mentalism
38. run after
39. arm
40. blase

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You can look up the words in the phrase individually using these links:   opposite ?   of ?   familiarity ?
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