Sorry, no online dictionaries contain the exact phrase familiarity opposite.
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Reverse dictionary results:
1. converse
2. conversing
3. eye
4. home
5. old
6. cold
7. coy
8. newness
9. freedom
10. know
11. knowledge
12. liberty
13. conversant
14. custom
15. experiment
16. experimenting
17. illiterate
18. intelligence
19. propagate
20. arm
21. blase
22. cousin
23. discourse
24. nickname
25. pug
26. shy
27. analytical
28. booing
29. boom
30. bow
31. critical
32. cross
33. diligence
34. exhibitionism
35. expert
36. free
37. freeing
38. hook
39. innocence
40. meet

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You can look up the words in the phrase individually using these links:   familiarity ?   opposite ?
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fami*to search for words beginning with fami, or
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