Usually means: Completely dissimilar, utterly unalike.
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We found 6 dictionaries that define the word as different as chalk and cheese:

General (3 matching dictionaries)
  1. as different as chalk and cheese: Oxford Learner's Dictionaries
  2. as different as chalk and cheese: Collins English Dictionary
  3. as different as chalk and cheese: TheFreeDictionary.com

Computing (1 matching dictionary)
  1. as different as chalk and cheese: Encyclopedia

Medicine (1 matching dictionary)
  1. as different as chalk and cheese: Medical dictionary

Miscellaneous (1 matching dictionary)
  1. as different as chalk and cheese: Idioms



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