Usually means: Space-based missile defense system.
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We found 10 dictionaries that define the word Strategic Defense Initiative:

General (8 matching dictionaries)
  1. strategic defense initiative: Longman Dictionary of Contemporary English
  2. Strategic Defense Initiative: Oxford Learner's Dictionaries
  3. Strategic Defense Initiative, the Strategic Defense Initiative: Collins English Dictionary
  4. Strategic Defense Initiative: Wiktionary
  5. Strategic Defense Initiative: The Wordsmyth English Dictionary-Thesaurus
  6. strategic defense initiative: Dictionary.com
  7. Strategic Defense Initiative: Wikipedia, the Free Encyclopedia
  8. Strategic Defense Initiative: TheFreeDictionary.com

Computing (1 matching dictionary)
  1. Strategic Defense Initiative: Encyclopedia

Miscellaneous (1 matching dictionary)
  1. Political (No longer online)

Definitions from Wiktionary (Strategic Defense Initiative)

noun:  (historical) A system proposed by U.S. President Ronald Reagan on March 23, 1983, to use ground-based and space-based systems to protect the United States from attack by strategic nuclear ballistic missiles.

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